About me

Vladimir K. Patchev
M.D. Ph.D.

If not me, who else?

If not now, then when?

This attitude has warranted my professional succes while shifting gears from academic research to corporate drug discovery, to clinical practice, to scientific and business consulting... and it has worked for 35 years on three continents.

Just name your task and see how swift and flawless the job can be done.

General profile

M.D./Ph.D. with multidisciplinary experience in:
  • pharmaceutical R&D
  • clinical study design and supervision
  • product development and positioning
  • business development and licensing
  • drug re-profiling and indication expansion,
  • translational medicine and biomarkers
  • corporate research outsourcing
  • industry-academe collaboration
  • medical and scientific writing and publishing

Skills & Record

Language skills

  • English fluent

  • German fluent

  • Russian fluent

  • French basic knowledge

  • Bulgarian mother tongue

Working style

  • Delivery-focused problem-solving approach
  • Customer-oriented work style
  • Documented flexibility in changing business environment
  • Proven leadership and recognition in corporate and academic environment
  • Record of academic excellence and extramural support recruitment
  • Documented teaching experience (medicine, pharmaceutical R&D)
  • Working contacts to international key opinion leaders in several medical disciplines 

Publication record

  • +60 full papers in peer-reviewed periodicals
  • 1 monograph
  • 2 book chapters
  • +20 invited talks and abstracts at major international meetings
  • 6 patents and 4 pending applications

Collaboration on Guidelines

2021

DEGUM S2e Leitlinie „Fraktursonografie“ AWMF 085-003

Koordinator: PD Dr. Ole Ackermann (Duisburg)

2020

DGGG/DEGUM S3-Leitlinie „Fetale Überwachung“ (Indikation und Methodik zur fetalen Zustandsdiagnostik in der Schwangerschaft) AWMF 015-089

Koordinator: Prof. Sven Schiermeier (Uni Witten/Herdecke)

2019

DDG S3 Leitlinie „Diabetes in der Schwangerschaft“ AWMF 057-023

Koordinator: PD Dr. Martin Füchtenbusch (München)

2019

DGGG Leitlinie-Update „Brustentzündungen in der Stillzeit“ AWMF 015-071

Koordinator: Prof. Michael Abou-Dakn (Berlin)

2019

DGGG/DEGUM S2e Leitlinie „Überwachung und Betreuung von Zwillingsschwangerschaften“ AWMF 015-087

Koordinator: Prof. Kurt Hecher (Hamburg)

2018

DGGG/DDG S3-Leitlinie „Adipositas in der Schwangerschaft Diagnostik, Therapie und Nachsorge“ AWMF 057–008

Koordinator: Prof. Ute Schäfer-Graf (Berlin)

2018

DGGG/DDG S3 Leitlinie „Gestationsdiabetes mellitus“ AWMF 057-028

Koordinator: Prof. Ute Schäfer-Graf (Berlin)

Year

Sponsor Society (Germany)
Guidelines title

2018

  • Gynecology and Obstetrics
  • Diabetes

Gestational diabetes mellitus

2018

  • Gynecology and Obstetrics
  • Diabetes
Adiposity in pregnancy

2019

  • Gynecology and Obstetrics
  • Ultrasound in Medicine
Monitoring and management of twin pregnancies

2019

  • Gynecology and Obstetrics
Breast inflammation in lactation

2019

  • Diabetes
Diabetes in pregnancy

2020

  • Gynecology and Obstetrics
  • Ultrasound in Medicine
Fetal monitoring

2021

  • Ultrasound in Medicine
Fracture sonography

Curriculum Vitae

Feb 2017 – Feb 2018

Scientific Writer

Center for Infectious Diseases and Infection Control, 

Jena University Hospital, Jena, Germany

  • Scientific publications 
  • Study report drafting and presentation
Mar 2014 – Feb 2017

Project Manager / Medical Writer

Center for Clinical Studies,

Jena University Hospital, Jena, Germany

  • Design and management of clinical trials and registries
  • Contribution to the development of clinical therapeutic guidelines
  • Teaching responsibility in GCP courses
  • Preparation of extramural grant applications
  • Scientific publications
Jan 2012 – Feb 2014

Resident Physician Neuro-Ophthalmology, Scientific Advisor

Eye Clinic Dr. Schönewolf

Königs Wusterhausen, Germany

  • Neuro-ophthalmologic and electrophysiological diagnostics

  • Clinical study conduct co-ordination

Jan 2007 – Dec 2011

Manager; Product LCM, Translational and Biomarker Issues
Women’s HealthCare, Global Drug Discovery

Bayer HealthCare, Berlin, Germany

 

  • Product life cycle management and repositioning

  • Business development and in-licensing advisor

  • Medical aspects of product positioning (emerging markets)

  • Translational and biomarker issues of drug development

Jun 2002 – Dec 2006

Head; Department Male Health Care
Research Business Unit “Gynecology and Andrology”

Schering AG, Jena, Germany

  • Drug discovery for male hormone therapy (small molecules)

  • Innovative therapy of benign disorders of the male urogenital tract (gene therapy)

Aug 1996 – Jun 2002

Head; Preclinical Research Division

Jenapharm GmbH & Co KG, Jena Germany

  • Discovery portfolios in fertility control, menopausal health, male hormone therapy, aging-related disorders

  • Clinical development and product life cycle management

  • Business development and licensing policy 

Jun 1992 – Aug 1996

Senior Scientist and Group Leader

Max Planck Institute of Psychiatry, Munich, Germany

  • Research in biological psychiatry, neurobiology of development and aging, drug abuse liability

Sep 1993 – Dec 1993

Jan 1995 – Mar 1995

Guest Professor

Tokyo Metropolitan Institute of Neuroscience, Tokyo, Japan

  • Co-ordination of international research projects (developmental neuroscience)

Nov 1990 – Jun 1992

Fogarty Visiting Scholar

NICHD, National Institutes of Health, Bethesda, USA

  • Research in neuroscience and immunology

Sep 1989 – Jun 1992

Head; Dept. of Neuroendocrinology and Immunology
Institute of Biology and Immunology of Reproduction

Bulgarian Academy of Sciences, Sofia, Bulgaria

  • Research in neuroscience, endocrinology and immunology

Jun 1982 – Sep 1989

Laboratory Leader “Interoceptive signaling and behavior”
Brain Research Institute

Bulgarian Academy of Sciences, Sofia, Bulgaria

  • Basic research in neuroscience

  • Clinical research in psychiatry

Selection of peer-reviewed publications

ESBL colonization and acquisition in a hospital population: The molecular epidemiology and transmission of resistance genes. Hagel S, Makarewicz O, Hartung A, Weiß D, Stein C, Brandt C, Schumacher U, Ehricht R, Patchev V, Pletz MW. PLoS One. 2019 Jan 14;14(1):e0208505. doi: 10.1371/journal.pone.0208505. eCollection 2019.

 

A Nosocomial Foodborne Outbreak of a VIM Carbapenemase-Expressing Citrobacter freundii. Pletz MW, Wollny A, Dobermann UH, Rödel J, Neubauer S, Stein C, Brandt C, Hartung A, Mellmann A, Trommer S, Edel B, Patchev V, Makarewicz O, Maschmann J. Clin Infect Dis. 2018 Jun 18;67(1):58-64. doi: 10.1093/cid/ciy034.

 

Gestationsdiabetes mellitus (GDM). Diagnosis, Therapie und Nachsorge. Praxisempfehlung - Kurzfassung der S3-Leitlinie (AWMF Reg. # 057-008). Schäfer-Graf U, et al.,  Patchev V, Nothacker M.  Diabetologie und Stoffwechsel. 2018, 13(S 02): S174-S184. (German).

 

Sepsis-associated Purpura Fulminans International Registry--Europe (SAPFIRE). Brunkhorst FM, Patchev V. Med Klin Intensivmed Notfmed. 2014 Nov;109(8):591-5. (German).

 

Telemetric assessment of referred vaginal hyperalgesia and the effect of indomethacin in a rat model of endometriosis. Dmitrieva N, Faircloth EK, Pyatok S, Sacher F, Patchev VFront Pharmacol. 2012 Aug 30;3:158. 

 

Endpoints of drug discovery for menopausal vasomotor symptoms: interpretation of data from a proxy of disease. Prelle K, Igl BW, Obendorf M, Girbig D, Lehmann T, Patchev VKMenopause. 2012 Aug;19(8):909-15. 

 

A dynamic model of circadian rhythms in rodent tail skin temperature for comparison of drug effects. Girbig D, Keller K, Prelle K, Patchev V, Vonk R, Igl BW. J Circadian Rhythms. 2012 Jan 5;10(1):1. 

 

Ontogeny of gender-specific responsiveness to stress and glucocorticoids in the rat and its determination by the neonatal gonadal steroid environment. Patchev VK, Hayashi S, Orikasa C, Almeida OF. Stress. 1999 Aug;3(1):41-54. 

 

Neurotrophic estrogens: essential profile and endpoints for drug discovery. Patchev VK, Bachurin SO, Albers M, Fritzemeier KH, Papadopoulos V. Drug Discov Today. 2008 Sep;13(17-18):734-47. 

 

The role of ERalpha and ERbeta in the prostate: insights from genetic models and isoform-selective ligands. McPherson SJ, Ellem SJ, Patchev V, Fritzemeier KH, Risbridger GP. Ernst Schering Found Symp Proc. 2006;(1):131-47. Review.

 

FoxG1, a member of the forkhead family, is a corepressor of the androgen receptor. Obendorf M, Meyer R, Henning K, Mitev YA, Schröder J, Patchev VK, Wolf SS. J Steroid Biochem Mol Biol. 2007 May;104(3-5):195-207. 

 

A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR. Wolf SS, Patchev VK, Obendorf M. Arch Biochem Biophys. 2007 Apr 1;460(1):56-66

 

Experimental models of stress. Patchev VK, Patchev AV. Dialogues Clin Neurosci. 2006;8(4):417-32. Review.

 

Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice. Patchev AV, Fischer D, Wolf SS, Herkenham M, Götz F, Gehin M, Chambon P, Patchev VK, Almeida OF. FASEB J. 2007 Jan;21(1):231-8

 

Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia. McPherson SJ, Ellem SJ, Simpson ER, Patchev V, Fritzemeier KH, Risbridger GP. Endocrinology. 2007 Feb;148(2):566-74

 

Interactions of sex steroids with mechanisms of inflammation. Obendorf M, Patchev VKCurr Drug Targets Inflamm Allergy. 2004 Dec;3(4):425-33. Review.

 

Neurotropic action of androgens: principles, mechanisms and novel targets. Patchev VK, Schroeder J, Goetz F, Rohde W, Patchev AV. Exp Gerontol. 2004 Nov-Dec;39(11-12):1651-60. Review.

 

Gender differences in the regulation of 3 alpha-hydroxysteroid dehydrogenase in rat brain and sensitivity to neurosteroid-mediated stress protection. Mitev YA, Darwish M, Wolf SS, Holsboer F, Almeida OF, Patchev VK. Neuroscience. 2003;120(2):541-9.

 

Developmental expression profiles and distinct regional estrogen responsiveness suggest a novel role for the steroid receptor coactivator SRC-1 as discriminative amplifier of estrogen signaling in the rat brain. Mitev YA, Wolf SS, Almeida OF, Patchev VKFASEB J. 2003 Mar;17(3):518-9

 

Selected aspects of endocrine pharmacology of the aging male. Oettel M, Hübler D, Patchev VExp Gerontol. 2003 Jan-Feb;38(1-2):189-98. Review.

 

17 Alpha-oestradiol and 17 beta-oestradiol do not affect basal and follicle-stimulating hormone-stimulated inhibin B secretion by highly purified rat Sertoli cells. Berlau J, Roemer W, Oettel M, Hipler UC, Patchev V, Schreiber G. Andrologia. 2000 Nov;32(6):345-9.

 

Plasticity of hippocampal corticosteroid receptors during aging in the rat. Hassan AH, Patchev VK, von Rosenstiel P, Holsboer F, Almeida OF. FASEB J. 1999 Jan;13(1):115-22.

 

Gender differences in ethanol preference and ingestion in rats. The role of the gonadal steroid environment. Almeida OF, Shoaib M, Deicke J, Fischer D, Darwish MH, Patchev VKJ Clin Invest. 1998 Jun 15;101(12):2677-85.

 

Chronic melatonin treatment counteracts glucocorticoid-induced dysregulation of the hypothalamic-pituitary-adrenal axis in the rat. Konakchieva R, Mitev Y, Almeida OF, Patchev VKNeuroendocrinology. 1998 Mar;67(3):171-80.

 

Gender specificity in the neural regulation of the response to stress: new leads from classical paradigms. Patchev VK, Almeida OF. Mol Neurobiol. 1998 Feb;16(1):63-77. Review.

 

Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events. Patchev VK, Montkowski A, Rouskova D, Koranyi L, Holsboer F, Almeida OF. J Clin Invest. 1997 Mar 1;99(5):962-6.

 

Activational effects of gonadal steroids on hypothalamo-pituitary-adrenal regulation in the rat disclosed by response to dexamethasone suppression. Almeida OF, Canoine V, Ali S, Holsboer F, Patchev VKJ Neuroendocrinol. 1997 Feb;9(2):129-34.

 

The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus. Patchev VK, Hassan AH, Holsboer DF, Almeida OF. Neuropsychopharmacology. 1996 Dec;15(6):533-40.

 

Gonadal steroids exert facilitating and "buffering" effects on glucocorticoid-mediated transcriptional regulation of corticotropin-releasing hormone and corticosteroid receptor genes in rat brain. Patchev VK, Almeida OF. J Neurosci. 1996 Nov 1;16(21):7077-84.

 

Exacerbation of apoptosis in the dentate gyrus of the aged rat by dexamethasone and the protective role of corticosterone. Hassan AH, von Rosenstiel P, Patchev VK, Holsboer F, Almeida OF. Exp Neurol. 1996 Jul;140(1):43-52.

 

Lactation as a model for naturally reversible hypercorticalism plasticity in the mechanisms governing hypothalamo-pituitary- adrenocortical activity in rats. Fischer D, Patchev VK, Hellbach S, Hassan AH, Almeida OF. J Clin Invest. 1995 Sep;96(3):1208-15.

 

Regulation of rat mineralocorticoid receptor expression in neurons by progesterone. Castrén M, Patchev VK, Almeida OF, Holsboer F, Trapp T, Castrén E. Endocrinology. 1995 Sep;136(9):3800-6.

 

Differences in arylalkylamine N-acetyltransferase activity between inflammatory disease-susceptible Lewis and -resistant Fischer rats. Mastorakos G, Patchev VK, Chader GJ, Chrousos GP, Gaudet SJ. Neuroendocrinology. 1995 Jul;62(1):71-8.

 

Corticosteroid regulation of gene expression and binding characteristics of vasopressin receptors in the rat brain. Patchev VK, Almeida OF. Eur J Neurosci. 1995 Jul 1;7(7):1579-83.

 

Implications of estrogen-dependent brain organization for gender differences in hypothalamo-pituitary-adrenal regulation. Patchev VK, Hayashi S, Orikasa C, Almeida OF. FASEB J. 1995 Mar;9(5):419-23.

 

Oxytocin-stimulated release of adrenocorticotropin from the rat pituitary is mediated by arginine vasopressin receptors of the V1b type. Schlosser SF, Almeida OF, Patchev VK, Yassouridis A, Elands J. Endocrinology. 1994 Nov;135(5):2058-63.

 

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus. Patchev VK, Shoaib M, Holsboer F, Almeida OF. Neuroscience. 1994 Sep;62(1):265-71.

 

Regulation of HSP90 and corticosteroid receptor mRNA by corticosterone levels in vivo. Patchev VK, Brady LS, Karl M, Chrousos GP. Mol Cell Endocrinol. 1994 Jul;103(1-2):57-64.

 

Effects of excitatory amino acid transmitters on hypothalamic corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP) release in vitro: implications in pituitary-adrenal regulation. Patchev VK, Karalis K, Chrousos GP. Brain Res. 1994 Jan 7;633(1-2):312-6.

 

Release of hypothalamic corticotropin-releasing hormone and arginine-vasopressin by interleukin 1 beta and alpha MSH: studies in rats with different susceptibility to inflammatory disease. Zelazowski P, Patchev VK, Zelazowska EB, Chrousos GP, Gold PW, Sternberg EM. Brain Res. 1993 Dec 17;631(1):22-6.

 

Oxytocin binding sites in rat limbic and hypothalamic structures: site-specific modulation by adrenal and gonadal steroids. Patchev VK, Schlosser SF, Hassan AH, Almeida OF. Neuroscience. 1993 Dec;57(3):537-43.

 

Increased arginine vasopressin secretion may participate in the enhanced susceptibility of Lewis rats to inflammatory disease. Patchev VK, Mastorakos G, Brady LS, Redwine J, Wilder RL, Chrousos GP. Neuroendocrinology. 1993 Jul;58(1):106-10.

 

Effect of single and repeated immobilization stress on the heat shock protein 70/90 system of the rat: glucocorticoid-independent, reversible reduction of Hsp90 in the liver and spleen. Vamvakopoulos NC, Fukuhara K, Patchev V, Chrousos GP. Neuroendocrinology. 1993 Jun;57(6):1057-65.

 

Suppression of hypothalamic-pituitary-adrenal axis responsiveness to stress in a rat model of acute cholestasis. Swain MG, Patchev V, Vergalla J, Chrousos G, Jones EA. J Clin Invest. 1993 May;91(5):1903-8.

 

Pituitary-adrenal function and hypothalamic beta-endorphin release in vitro following food deprivation. Mitev Y, Almeida OF, Patchev VBrain Res Bull. 1993;30(1-2):7-10.

 

Increased plasma concentrations, hypothalamic content, and in vitro release of arginine vasopressin in inflammatory disease-prone, hypothalamic corticotropin-releasing hormone-deficient Lewis rats. Patchev VK, Kalogeras KT, Zelazowski P, Wilder RL, Chrousos GP. Endocrinology. 1992 Sep;131(3):1453-7.

 

Neuroendocrine and neurochemical consequences of long-term sleep deprivation in rats: similarities to some features of depression. Patchev V, Felszeghy K, Korányi L. Homeost Health Dis. 1991;33(3):97-108.

 

Adrenalectomy and experimental hypercorticalism modulate the basal, corticotropin-releasing-hormone- and arginine-vasopressin-stimulated release of hypothalamic beta-endorphin. Patchev VK, Racké K, Almeida OF. Neuroendocrinology. 1991 Aug;54(2):111-7.

 

Phospholipid and glycolipid synthesis in brain structures of Brattleboro rats. Dishkelov A, Mitev Y, Patchev VLife Sci. 1989;45(25):2401-4.

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